HIV‐associated chronic immune activation
Identifieur interne : 000204 ( France/Analysis ); précédent : 000203; suivant : 000205HIV‐associated chronic immune activation
Auteurs : Mirko Paiardini [États-Unis] ; Michaela Müller-Trutwin [France]Source :
- Immunological Reviews [ 0105-2896 ] ; 2013-07.
English descriptors
- Teeft :
- Activation, Acute infection, Acute phase, Agms, Antiretroviral, Antiretroviral therapy, Cardiovascular disease, Ccr5, Ccr5 expression, Cell activation, Cell depletion, Central memory, Chronic, Chronic infection, Chronic phase, Clin, Coagulation, Cytokine, Dendritic, Disease progression, Epithelial, Gastrointestinal tract, Germinal centers, High levels, Hivinfected, Hivinfected individuals, Homeostasis, Homeostatic, Homeostatic proliferation, Human virus, Human virus infection, Human virus type, Immune, Immune activation, Immune cells, Immune responses, Immune system, Immunol, Immunologic, Immunological, Immunological reviews, Immunological reviews paiardini, Immunomodulatory, Infection, Interferon, Intestinal, John wiley sons, Lymph, Lymph nodes, Lymphocyte, Lymphoid, Lymphoid tissue, Macaque, Mangabey, Microbial, Microbial translocation, Monocyte, Mucosal, Mucosal integrity, Mucosal sites, Natural history, Natural hosts, Ndings, Node, Paiardini, Pathogenesis, Pathogenic, Peripheral blood, Personal communication, Plasma levels, Plasmacytoid, Plasmacytoid dendritic cells, Plo, Primary infection, Primate, Primates, Probiotic, Progression, Proliferation, Psoriatic arthritis, Rapa, Rapamycin, Recent studies, Recent study, Receptor, Relative contribution, Replication, Residual, Rhesus, Rhesus macaques, Simian, Simian virus, Simian virus infection, Sivagm, Sivmac, Sooty, Sooty mangabeys, Subset, Supplementation, Suppressive, Target cells, Translocation, Treg, Tregs, Unpublished data, Vicious cycle, Viral, Viral load, Viral replication, Viremia, Virol, Virus, Virus infection, Wiley.
Abstract
Systemic chronic immune activation is considered today as the driving force of CD4+ T‐cell depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune activation persists even in HIV‐infected patients in which viral replication is successfully inhibited by anti‐retroviral therapy, with the extent of this residual immune activation being associated with CD4+ T‐cell loss. Unfortunately, the causal link between chronic immune activation and CD4+ T‐cell loss has not been formally established. This article provides first a brief historical overview on how the perception of the causative role of immune activation has changed over the years and lists the different kinds of immune activation characteristic of human immunodeficiency virus (HIV) infection. The mechanisms proposed to explain the chronic immune activation are multiple and are enumerated here, as well as the mechanisms proposed on how chronic immune activation could lead to AIDS. In addition, we summarize the lessons learned from natural hosts that know how to ‘show AIDS the door’, and discuss how these studies informed the design of novel immune modulatory interventions that are currently being tested. Finally, we review the current approaches aimed at targeting chronic immune activation and evoke future perspectives.
Url:
DOI: 10.1111/imr.12079
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000416
- to stream Istex, to step Curation: 000416
- to stream Istex, to step Checkpoint: 000263
- to stream Main, to step Merge: 001212
- to stream Main, to step Curation: 001211
- to stream Main, to step Exploration: 001211
- to stream France, to step Extraction: 000204
Links to Exploration step
ISTEX:1EB392A99746558E8CC569E249CF34D9DAF93AA2Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">HIV‐associated chronic immune activation</title><author><name sortKey="Paiardini, Mirko" sort="Paiardini, Mirko" uniqKey="Paiardini M" first="Mirko" last="Paiardini">Mirko Paiardini</name></author><author><name sortKey="Muller Rutwin, Michaela" sort="Muller Rutwin, Michaela" uniqKey="Muller Rutwin M" first="Michaela" last="Müller-Trutwin">Michaela Müller-Trutwin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1EB392A99746558E8CC569E249CF34D9DAF93AA2</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1111/imr.12079</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-ZM9VZ2LK-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000416</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000416</idno><idno type="wicri:Area/Istex/Curation">000416</idno><idno type="wicri:Area/Istex/Checkpoint">000263</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000263</idno><idno type="wicri:doubleKey">0105-2896:2013:Paiardini M:hiv:associated:chronic</idno><idno type="wicri:Area/Main/Merge">001212</idno><idno type="wicri:Area/Main/Curation">001211</idno><idno type="wicri:Area/Main/Exploration">001211</idno><idno type="wicri:Area/France/Extraction">000204</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">HIV‐associated chronic immune activation</title><author><name sortKey="Paiardini, Mirko" sort="Paiardini, Mirko" uniqKey="Paiardini M" first="Mirko" last="Paiardini">Mirko Paiardini</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Department of Pathology and Laboratory Medicine, Emory University, GA, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Muller Rutwin, Michaela" sort="Muller Rutwin, Michaela" uniqKey="Muller Rutwin M" first="Michaela" last="Müller-Trutwin">Michaela Müller-Trutwin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Regulation of Retroviral infections Unit, Institut Pasteur, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Immunological Reviews</title><title level="j" type="sub">HIV Immunology</title><title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title><idno type="ISSN">0105-2896</idno><idno type="eISSN">1600-065X</idno><imprint><biblScope unit="vol">254</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="78">78</biblScope><biblScope unit="page" to="101">101</biblScope><biblScope unit="page-count">24</biblScope><date type="published" when="2013-07">2013-07</date></imprint><idno type="ISSN">0105-2896</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-2896</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Activation</term><term>Acute infection</term><term>Acute phase</term><term>Agms</term><term>Antiretroviral</term><term>Antiretroviral therapy</term><term>Cardiovascular disease</term><term>Ccr5</term><term>Ccr5 expression</term><term>Cell activation</term><term>Cell depletion</term><term>Central memory</term><term>Chronic</term><term>Chronic infection</term><term>Chronic phase</term><term>Clin</term><term>Coagulation</term><term>Cytokine</term><term>Dendritic</term><term>Disease progression</term><term>Epithelial</term><term>Gastrointestinal tract</term><term>Germinal centers</term><term>High levels</term><term>Hivinfected</term><term>Hivinfected individuals</term><term>Homeostasis</term><term>Homeostatic</term><term>Homeostatic proliferation</term><term>Human virus</term><term>Human virus infection</term><term>Human virus type</term><term>Immune</term><term>Immune activation</term><term>Immune cells</term><term>Immune responses</term><term>Immune system</term><term>Immunol</term><term>Immunologic</term><term>Immunological</term><term>Immunological reviews</term><term>Immunological reviews paiardini</term><term>Immunomodulatory</term><term>Infection</term><term>Interferon</term><term>Intestinal</term><term>John wiley sons</term><term>Lymph</term><term>Lymph nodes</term><term>Lymphocyte</term><term>Lymphoid</term><term>Lymphoid tissue</term><term>Macaque</term><term>Mangabey</term><term>Microbial</term><term>Microbial translocation</term><term>Monocyte</term><term>Mucosal</term><term>Mucosal integrity</term><term>Mucosal sites</term><term>Natural history</term><term>Natural hosts</term><term>Ndings</term><term>Node</term><term>Paiardini</term><term>Pathogenesis</term><term>Pathogenic</term><term>Peripheral blood</term><term>Personal communication</term><term>Plasma levels</term><term>Plasmacytoid</term><term>Plasmacytoid dendritic cells</term><term>Plo</term><term>Primary infection</term><term>Primate</term><term>Primates</term><term>Probiotic</term><term>Progression</term><term>Proliferation</term><term>Psoriatic arthritis</term><term>Rapa</term><term>Rapamycin</term><term>Recent studies</term><term>Recent study</term><term>Receptor</term><term>Relative contribution</term><term>Replication</term><term>Residual</term><term>Rhesus</term><term>Rhesus macaques</term><term>Simian</term><term>Simian virus</term><term>Simian virus infection</term><term>Sivagm</term><term>Sivmac</term><term>Sooty</term><term>Sooty mangabeys</term><term>Subset</term><term>Supplementation</term><term>Suppressive</term><term>Target cells</term><term>Translocation</term><term>Treg</term><term>Tregs</term><term>Unpublished data</term><term>Vicious cycle</term><term>Viral</term><term>Viral load</term><term>Viral replication</term><term>Viremia</term><term>Virol</term><term>Virus</term><term>Virus infection</term><term>Wiley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Systemic chronic immune activation is considered today as the driving force of CD4+ T‐cell depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune activation persists even in HIV‐infected patients in which viral replication is successfully inhibited by anti‐retroviral therapy, with the extent of this residual immune activation being associated with CD4+ T‐cell loss. Unfortunately, the causal link between chronic immune activation and CD4+ T‐cell loss has not been formally established. This article provides first a brief historical overview on how the perception of the causative role of immune activation has changed over the years and lists the different kinds of immune activation characteristic of human immunodeficiency virus (HIV) infection. The mechanisms proposed to explain the chronic immune activation are multiple and are enumerated here, as well as the mechanisms proposed on how chronic immune activation could lead to AIDS. In addition, we summarize the lessons learned from natural hosts that know how to ‘show AIDS the door’, and discuss how these studies informed the design of novel immune modulatory interventions that are currently being tested. Finally, we review the current approaches aimed at targeting chronic immune activation and evoke future perspectives.</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Paiardini, Mirko" sort="Paiardini, Mirko" uniqKey="Paiardini M" first="Mirko" last="Paiardini">Mirko Paiardini</name></noRegion><name sortKey="Paiardini, Mirko" sort="Paiardini, Mirko" uniqKey="Paiardini M" first="Mirko" last="Paiardini">Mirko Paiardini</name></country><country name="France"><region name="Île-de-France"><name sortKey="Muller Rutwin, Michaela" sort="Muller Rutwin, Michaela" uniqKey="Muller Rutwin M" first="Michaela" last="Müller-Trutwin">Michaela Müller-Trutwin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000204 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000204 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:1EB392A99746558E8CC569E249CF34D9DAF93AA2
|texte= HIV‐associated chronic immune activation
}}
| This area was generated with Dilib version V0.6.33. |  |